Desmopressin intranasal solution availability

We contacted Ferring, who manufacture this product, on 21 October to check on its availability. They say that they should have stock of this by the 1st November as promised.

In the meantime, it may be worth trying a couple of other pharmacies in your local area as some may still have stock on their shelves. If this is not successful, Ferring advises that you see your GP to ask for an alternative product to be prescribed.

Ferring have given us very approximate equivalence guidelines:

  • You may require 10 to 20 times a greater dose of desmopressin with the tablet oral formulations than with the nasal formulations. So, if a patient is on a nasal (spray or intranasal) dose of 10mcg (0.1 ml) twice a day, then a suitable tablet oral dose may be 100mcg or 200mcg twice a day
  • The Melt dose is then derived from tablet conversion, as follows:

 

DDAVP Formulation

Current dose

Comparable Melt dose

(DDAVP Melt)

Comparable tablet dose

(Desmotabs)

Nasal Spray (Desmospray)

10 mcg (0.1 ml)

60 mcg or 120 mcg

100 mcg or 200 mcg

Intranasal (tube)

(Desmopressin intranasal)

10 mcg (0.1 ml)

60 mcg or 120 mcg

100 mcg or 200 mcg

Tablet

(Desmotabs)

100 mcg

60 mcg

 

Tablet

(Desmotabs)

200 mcg

120 mcg

 

 

So the tablet oral dose in the above example would convert to a Melt dose of approximately 60mcg or 120mcg twice a day.

The equivalence guidelines are very approximate – it really is sensible to start on the lowest dose and titrate upwards, according to response and your specialist’s advice.